Spyre Therapeutics, Inc.

King-Jones Heidy bought 400 shares of SYRE on 2 September. They now own 3,245 SYRE shares.

King-Jones Heidy sold 400 shares of SYRE on 2 September. They now own 511,411 SYRE shares.

King-Jones Heidy sold 400 shares of SYRE on 2 September. They now own 2,845 SYRE shares.

Burrows Scott L sold 18,232 shares of SYRE on 2 September. They now own 79,762 SYRE shares.

Turtle Cameron sold 400 shares of SYRE on 1 September. They now own 552,540 SYRE shares.

Burrows Scott L sold 900 shares of SYRE on 1 September. They now own 104,594 SYRE shares.

Burrows Scott L sold 2,016 shares of SYRE on 1 September. They now own 98,194 SYRE shares.

King-Jones Heidy sold 16,548 shares of SYRE on 1 September. They now own 9,451 SYRE shares.

Burrows Scott L sold 7,500 shares of SYRE on 1 September. They now own 337,357 SYRE shares.

King-Jones Heidy sold 4,845 shares of SYRE on 1 September. They now own 25,999 SYRE shares.

Turtle Cameron sold 8,400 shares of SYRE on 1 September. They now own 556,640 SYRE shares.

King-Jones Heidy sold 400 shares of SYRE on 1 September. They now own 2,845 SYRE shares.

King-Jones Heidy sold 27,999 shares of SYRE on 1 September. They now own 511,811 SYRE shares.

Burrows Scott L bought 7,500 shares of SYRE on 1 September. They now own 105,494 SYRE shares.

King-Jones Heidy bought 27,999 shares of SYRE on 1 September. They now own 30,844 SYRE shares.

King-Jones Heidy sold 6,206 shares of SYRE on 1 September. They now own 3,245 SYRE shares.

Turtle Cameron sold 3,700 shares of SYRE on 1 September. They now own 552,940 SYRE shares.

Turtle Cameron sold 2,500 shares of SYRE on 1 September. They now own 565,040 SYRE shares.

Burrows Scott L sold 200 shares of SYRE on 1 September. They now own 97,994 SYRE shares.

Burrows Scott L sold 4,384 shares of SYRE on 1 September. They now own 100,210 SYRE shares.

Albers Jeffrey W. bought 5,000 shares of SYRE on 7 August. They now own 5,000 SYRE shares.

Albers Jeffrey W. sold 10,000 shares of SYRE on 7 August. They now own 9,360 SYRE shares.

Albers Jeffrey W. sold 5,000 shares of SYRE on 7 August. They now own 45,000 SYRE shares.

Albers Jeffrey W. sold 5,000 shares of SYRE on 7 August. They now own 0 SYRE shares.

Albers Jeffrey W. sold 8,000 shares of SYRE on 7 August. They now own 19,360 SYRE shares.

Turtle Cameron sold 800 shares of SYRE on 3 August. They now own 581,740 SYRE shares.

Burrows Scott L sold 7,500 shares of SYRE on 3 August. They now own 344,857 SYRE shares.

Turtle Cameron sold 5,635 shares of SYRE on 3 August. They now own 568,948 SYRE shares.

Turtle Cameron sold 7,157 shares of SYRE on 3 August. They now own 574,583 SYRE shares.

Burrows Scott L sold 5,100 shares of SYRE on 3 August. They now own 100,394 SYRE shares.

Turtle Cameron sold 16 shares of SYRE on 3 August. They now own 567,540 SYRE shares.

Burrows Scott L sold 100 shares of SYRE on 3 August. They now own 97,994 SYRE shares.

Turtle Cameron sold 1,392 shares of SYRE on 3 August. They now own 567,556 SYRE shares.

Burrows Scott L bought 7,500 shares of SYRE on 3 August. They now own 105,494 SYRE shares.

Burrows Scott L sold 2,300 shares of SYRE on 3 August. They now own 98,094 SYRE shares.

Sloan Sheldon bought 8,334 shares of SYRE on 1 July. They now own 8,334 SYRE shares.

Burrows Scott L bought 7,500 shares of SYRE on 1 July. They now own 105,494 SYRE shares.

Turtle Cameron sold 590 shares of SYRE on 1 July. They now own 582,540 SYRE shares.

Burrows Scott L sold 7,500 shares of SYRE on 1 July. They now own 352,357 SYRE shares.

Turtle Cameron sold 4,234 shares of SYRE on 1 July. They now own 583,130 SYRE shares.

Sloan Sheldon sold 6,500 shares of SYRE on 1 July. They now own 1,834 SYRE shares.

Burrows Scott L sold 5,775 shares of SYRE on 1 July. They now own 99,719 SYRE shares.

Burrows Scott L sold 1,725 shares of SYRE on 1 July. They now own 97,994 SYRE shares.

Sloan Sheldon sold 1,834 shares of SYRE on 1 July. They now own 0 SYRE shares.

Turtle Cameron sold 10,176 shares of SYRE on 1 July. They now own 587,364 SYRE shares.

Sloan Sheldon sold 8,334 shares of SYRE on 1 July. They now own 305,000 SYRE shares.

Burrows Scott L sold 5,000 shares of SYRE on 25 June. They now own 107,994 SYRE shares.

Burrows Scott L bought 15,000 shares of SYRE on 25 June. They now own 112,994 SYRE shares.

Burrows Scott L sold 10,000 shares of SYRE on 25 June. They now own 97,994 SYRE shares.

Burrows Scott L sold 15,000 shares of SYRE on 25 June. They now own 359,857 SYRE shares.

Fairmount Funds Management Llc sold 16,667 shares of SYRE on 23 June. They now own 0 SYRE shares.

Fairmount Funds Management Llc bought 666,680 shares of SYRE on 23 June. They now own 4,684,781 SYRE shares.

Fairmount Funds Management Llc sold 4,684,781 shares of SYRE on 23 June. They now own 0 SYRE shares.

Henderson Michael Thomas sold 20,000 shares of SYRE on 22 June. They now own 68,606 SYRE shares.

Sloan Sheldon sold 8,333 shares of SYRE on 3 June. They now own 0 SYRE shares.

Sloan Sheldon bought 8,333 shares of SYRE on 3 June. They now own 8,333 SYRE shares.

Sloan Sheldon sold 8,333 shares of SYRE on 3 June. They now own 313,334 SYRE shares.

Burrows Scott L sold 1,801 shares of SYRE on 1 June. They now own 103,693 SYRE shares.

Turtle Cameron sold 3,557 shares of SYRE on 1 June. They now own 608,983 SYRE shares.

Burrows Scott L sold 3,100 shares of SYRE on 1 June. They now own 97,994 SYRE shares.

Burrows Scott L sold 7,500 shares of SYRE on 1 June. They now own 374,857 SYRE shares.

Burrows Scott L sold 2,599 shares of SYRE on 1 June. They now own 101,094 SYRE shares.

Burrows Scott L bought 7,500 shares of SYRE on 1 June. They now own 105,494 SYRE shares.

Turtle Cameron sold 8,149 shares of SYRE on 1 June. They now own 600,834 SYRE shares.

Turtle Cameron sold 3,294 shares of SYRE on 1 June. They now own 597,540 SYRE shares.

Milligan Sandra bought 8,026 shares of SYRE on 27 May. They now own 8,026 SYRE shares.

Albers Jeffrey W. bought 8,026 shares of SYRE on 27 May. They now own 8,026 SYRE shares.

Henderson Michael Thomas bought 8,026 shares of SYRE on 27 May. They now own 8,026 SYRE shares.

Mckenna Mark C. bought 8,026 shares of SYRE on 27 May. They now own 8,026 SYRE shares.

Fairmount Funds Management Llc bought 8,026 shares of SYRE on 27 May. They now own 8,026 SYRE shares.

Stelzer Laurie bought 8,026 shares of SYRE on 27 May. They now own 8,026 SYRE shares.

Henderson Michael Thomas sold 19,269 shares of SYRE on 8 May. They now own 88,606 SYRE shares.

Henderson Michael Thomas sold 24,814 shares of SYRE on 8 May. They now own 107,875 SYRE shares.

Henderson Michael Thomas sold 2,404 shares of SYRE on 8 May. They now own 166,202 SYRE shares.

Henderson Michael Thomas sold 33,513 shares of SYRE on 8 May. They now own 132,689 SYRE shares.

Sloan Sheldon sold 12,777 shares of SYRE on 1 May. They now own 15,817 SYRE shares.

Sloan Sheldon sold 5,059 shares of SYRE on 1 May. They now own 400 SYRE shares.

Sloan Sheldon sold 10,358 shares of SYRE on 1 May. They now own 5,459 SYRE shares.

Burrows Scott L bought 12,500 shares of SYRE on 1 May. They now own 110,494 SYRE shares.

Sloan Sheldon sold 21,306 shares of SYRE on 1 May. They now own 57,027 SYRE shares.

Sloan Sheldon sold 78,333 shares of SYRE on 1 May. They now own 321,667 SYRE shares.

Turtle Cameron sold 300 shares of SYRE on 1 May. They now own 612,540 SYRE shares.

Burrows Scott L sold 12,500 shares of SYRE on 1 May. They now own 382,357 SYRE shares.

Turtle Cameron sold 5,300 shares of SYRE on 1 May. They now own 622,240 SYRE shares.

Sloan Sheldon sold 400 shares of SYRE on 1 May. They now own 0 SYRE shares.

Turtle Cameron sold 1,000 shares of SYRE on 1 May. They now own 617,640 SYRE shares.

Sloan Sheldon sold 19,656 shares of SYRE on 1 May. They now own 37,371 SYRE shares.

Sloan Sheldon sold 8,777 shares of SYRE on 1 May. They now own 28,594 SYRE shares.

Turtle Cameron sold 3,100 shares of SYRE on 1 May. They now own 614,540 SYRE shares.

Turtle Cameron sold 3,600 shares of SYRE on 1 May. They now own 618,640 SYRE shares.

Turtle Cameron sold 1,700 shares of SYRE on 1 May. They now own 612,840 SYRE shares.

Sloan Sheldon bought 78,333 shares of SYRE on 1 May. They now own 78,333 SYRE shares.

Burrows Scott L sold 12,500 shares of SYRE on 1 May. They now own 97,994 SYRE shares.

Sloan Sheldon sold 7,958 shares of SYRE on 1 April. They now own 0 SYRE shares.

Sloan Sheldon bought 7,958 shares of SYRE on 1 April. They now own 7,958 SYRE shares.

Burrows Scott L bought 7,500 shares of SYRE on 1 April. They now own 105,494 SYRE shares.

Burrows Scott L sold 6,200 shares of SYRE on 1 April. They now own 99,294 SYRE shares.

Burrows Scott L sold 7,500 shares of SYRE on 1 April. They now own 394,857 SYRE shares.

Turtle Cameron sold 12,344 shares of SYRE on 1 April. They now own 630,196 SYRE shares.

Turtle Cameron sold 2,656 shares of SYRE on 1 April. They now own 627,540 SYRE shares.

Sloan Sheldon sold 7,958 shares of SYRE on 1 April. They now own 87,542 SYRE shares.

Burrows Scott L sold 1,300 shares of SYRE on 1 April. They now own 97,994 SYRE shares.

Burrows Scott L sold 2,500 shares of SYRE on 3 March. They now own 402,357 SYRE shares.

Burrows Scott L sold 200 shares of SYRE on 3 March. They now own 97,994 SYRE shares.

Burrows Scott L sold 2,300 shares of SYRE on 3 March. They now own 98,194 SYRE shares.

Burrows Scott L bought 2,500 shares of SYRE on 3 March. They now own 100,494 SYRE shares.

Turtle Cameron sold 5,900 shares of SYRE on 2 March. They now own 651,640 SYRE shares.

Turtle Cameron sold 9,100 shares of SYRE on 2 March. They now own 642,540 SYRE shares.

Turtle Cameron sold 957 shares of SYRE on 2 February. They now own 671,583 SYRE shares.

Turtle Cameron sold 14,043 shares of SYRE on 2 February. They now own 657,540 SYRE shares.

Henderson Michael Thomas bought 63,227 shares of SYRE on 21 January. They now own 168,606 SYRE shares.

King-Jones Heidy bought 140,000 shares of SYRE on 9 January. They now own 140,000 SYRE shares.

Burrows Scott L bought 140,000 shares of SYRE on 9 January. They now own 140,000 SYRE shares.

Turtle Cameron bought 528,000 shares of SYRE on 9 January. They now own 528,000 SYRE shares.

Sloan Sheldon bought 140,000 shares of SYRE on 9 January. They now own 140,000 SYRE shares.

Turtle Cameron sold 2,191 shares of SYRE on 2 January. They now own 672,007 SYRE shares.

Turtle Cameron sold 100 shares of SYRE on 2 January. They now own 671,907 SYRE shares.

Turtle Cameron sold 12,709 shares of SYRE on 2 January. They now own 674,198 SYRE shares.

Turtle Cameron sold 4,005 shares of SYRE on 1 December. They now own 686,907 SYRE shares.

Turtle Cameron sold 10,995 shares of SYRE on 1 December. They now own 690,912 SYRE shares.

Turtle Cameron sold 28,155 shares of SYRE on 3 November. They now own 718,752 SYRE shares.

Turtle Cameron sold 16,845 shares of SYRE on 3 November. They now own 701,907 SYRE shares.

Burrows Scott L sold 18,428 shares of SYRE on 2 September. They now own 97,994 SYRE shares.

Milligan Sandra bought 25,000 shares of SYRE on 29 May. They now own 25,000 SYRE shares.

Stelzer Laurie bought 25,000 shares of SYRE on 29 May. They now own 25,000 SYRE shares.

Fairmount Funds Management Llc bought 25,000 shares of SYRE on 29 May. They now own 25,000 SYRE shares.

Mckenna Mark C. bought 25,000 shares of SYRE on 29 May. They now own 25,000 SYRE shares.

Albers Jeffrey W. bought 25,000 shares of SYRE on 29 May. They now own 25,000 SYRE shares.

Henderson Michael Thomas bought 25,000 shares of SYRE on 29 May. They now own 25,000 SYRE shares.

Burrows Scott L bought 95,500 shares of SYRE on 15 January. They now own 95,500 SYRE shares.

Turtle Cameron bought 370,000 shares of SYRE on 15 January. They now own 370,000 SYRE shares.

King-Jones Heidy bought 95,500 shares of SYRE on 15 January. They now own 95,500 SYRE shares.

Sloan Sheldon bought 95,500 shares of SYRE on 15 January. They now own 95,500 SYRE shares.

Henderson Michael Thomas bought 105,379 shares of SYRE on 10 January. They now own 105,379 SYRE shares.

Albers Jeffrey W. sold 6,700 shares of SYRE on 6 November. They now own 27,360 SYRE shares.

Albers Jeffrey W. sold 300 shares of SYRE on 25 October. They now own 34,060 SYRE shares.

Sloan Sheldon bought 400,000 shares of SYRE on 1 October. They now own 400,000 SYRE shares.

Sloan Sheldon bought 0 shares of SYRE on 1 October. They now own 0 SYRE shares.

Burrows Scott L sold 18,531 shares of SYRE on 3 September. They now own 116,422 SYRE shares.

Henderson Michael Thomas bought 11,323 shares of SYRE on 14 May. They now own 11,323 SYRE shares.

Stelzer Laurie bought 11,323 shares of SYRE on 14 May. They now own 11,323 SYRE shares.

Fairmount Funds Management Llc bought 11,323 shares of SYRE on 14 May. They now own 11,323 SYRE shares.

Milligan Sandra bought 0 shares of SYRE on 14 May. They now own 0 SYRE shares.

Albers Jeffrey W. bought 11,323 shares of SYRE on 14 May. They now own 11,323 SYRE shares.

Milligan Sandra bought 21,980 shares of SYRE on 14 May. They now own 21,980 SYRE shares.

Fairmount Funds Management Llc bought 3,639,680 shares of SYRE on 25 April. They now own 4,018,101 SYRE shares.

Fairmount Funds Management Llc sold 90,992 shares of SYRE on 25 April. They now own 346,045 SYRE shares.

Turtle Cameron bought 400 shares of SYRE on 15 February. They now own 746,907 SYRE shares.

Turtle Cameron bought 277,750 shares of SYRE on 1 February. They now own 277,750 SYRE shares.

Mckenna Mark C. bought 40,000 shares of SYRE on 1 February. They now own 40,000 SYRE shares.

Burrows Scott L bought 70,000 shares of SYRE on 1 February. They now own 70,000 SYRE shares.

King-Jones Heidy bought 63,000 shares of SYRE on 1 February. They now own 63,000 SYRE shares.

Mckenna Mark C. sold 477,000 shares of SYRE on 1 February. They now own 0 SYRE shares.

Fairmount Funds Management Llc bought 406,038 shares of SYRE on 29 December. They now own 406,038 SYRE shares.

Fairmount Funds Management Llc sold 3,435,480 shares of SYRE on 29 December. They now own 0 SYRE shares.

Fairmount Funds Management Llc bought 16,667 shares of SYRE on 7 December. They now own 16,667 SYRE shares.

Albers Jeffrey W. sold 859 shares of SYRE on 24 November. They now own 0 SYRE shares.

Albers Jeffrey W. bought 34,360 shares of SYRE on 24 November. They now own 34,360 SYRE shares.

Albers Jeffrey W. bought 50,000 shares of SYRE on 22 November. They now own 50,000 SYRE shares.