Prelude Therapeutics Incorporated

Bonita David P bought 38,000 shares of PRLD on 9 June. They now own 38,000 PRLD shares.

Sandor Victor bought 38,000 shares of PRLD on 9 June. They now own 38,000 PRLD shares.

Friedman Paul A bought 38,000 shares of PRLD on 9 June. They now own 38,000 PRLD shares.

Baker Bros. Advisors Lp bought 38,000 shares of PRLD on 9 June. They now own 38,000 PRLD shares.

Dorton Katina bought 38,000 shares of PRLD on 9 June. They now own 38,000 PRLD shares.

Babler Martin bought 38,000 shares of PRLD on 9 June. They now own 38,000 PRLD shares.

Morris Charles Q bought 450,000 shares of PRLD on 1 May. They now own 450,000 PRLD shares.

Ra Capital Management, L.P. bought 1,407,000 shares of PRLD on 27 April. They now own 1,407,000 PRLD shares.

Ra Capital Management, L.P. sold 1,407,000 shares of PRLD on 27 April. They now own 6,475,882 PRLD shares.

Bonita David P bought 1,689,189 shares of PRLD on 21 April. They now own 11,808,945 PRLD shares.

Baker Bros. Advisors Lp bought 114,601 shares of PRLD on 21 April. They now own 1,678,273 PRLD shares.

Orbimed Advisors Llc bought 1,126,126 shares of PRLD on 21 April. They now own 1,126,126 PRLD shares.

Ra Capital Management, L.P. bought 0 shares of PRLD on 21 April. They now own 7,882,882 PRLD shares.

Baker Bros. Advisors Lp bought 2,137,651 shares of PRLD on 21 April. They now own 20,105,994 PRLD shares.

Orbimed Advisors Llc bought 1,689,189 shares of PRLD on 21 April. They now own 11,808,945 PRLD shares.

Bonita David P bought 1,126,126 shares of PRLD on 21 April. They now own 1,126,126 PRLD shares.

Morris Charles Q bought 0 shares of PRLD on 15 April. They now own 0 PRLD shares.

Brusky Sean P. bought 0 shares of PRLD on 5 March. They now own 100,000 PRLD shares.

Brusky Sean P. bought 275,000 shares of PRLD on 5 March. They now own 0 PRLD shares.

Combs Andrew bought 230,000 shares of PRLD on 4 February. They now own 230,000 PRLD shares.

Vaddi Krishna bought 837,000 shares of PRLD on 4 February. They now own 837,000 PRLD shares.

Scherle Peggy bought 230,000 shares of PRLD on 4 February. They now own 230,000 PRLD shares.

Lim Bryant David bought 275,000 shares of PRLD on 4 February. They now own 275,000 PRLD shares.

Sandor Victor bought 121,285 shares of PRLD on 5 November. They now own 121,285 PRLD shares.

Dorton Katina bought 0 shares of PRLD on 17 October. They now own 0 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 October. They now own 18,750 PRLD shares.

Huang Jane sold 3,355 shares of PRLD on 4 October. They now own 86,917 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 October. They now own 90,272 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 July. They now own 28,125 PRLD shares.

Huang Jane sold 3,355 shares of PRLD on 4 July. They now own 80,897 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 July. They now own 84,252 PRLD shares.

Dier Mardi bought 38,000 shares of PRLD on 12 June. They now own 38,000 PRLD shares.

Bonita David P bought 38,000 shares of PRLD on 12 June. They now own 38,000 PRLD shares.

Babler Martin bought 38,000 shares of PRLD on 12 June. They now own 38,000 PRLD shares.

Friedman Paul A bought 38,000 shares of PRLD on 12 June. They now own 38,000 PRLD shares.

Scherer Paul C bought 0 shares of PRLD on 12 June. They now own 0 PRLD shares.

Baker Bros. Advisors Lp bought 76,000 shares of PRLD on 12 June. They now own 76,000 PRLD shares.

Sandor Victor bought 38,000 shares of PRLD on 12 June. They now own 38,000 PRLD shares.

Huang Jane sold 3,355 shares of PRLD on 4 April. They now own 74,877 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 April. They now own 37,500 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 April. They now own 78,232 PRLD shares.

Vaddi Krishna bought 675,000 shares of PRLD on 25 March. They now own 1,999,296 PRLD shares.

Combs Andrew bought 100,000 shares of PRLD on 25 March. They now own 480,123 PRLD shares.

Vaddi Krishna bought 15,000 shares of PRLD on 21 March. They now own 1,324,296 PRLD shares.

Vaddi Krishna bought 5,416 shares of PRLD on 20 March. They now own 1,309,296 PRLD shares.

Vaddi Krishna bought 9,106 shares of PRLD on 17 March. They now own 1,303,880 PRLD shares.

Vaddi Krishna bought 29,999 shares of PRLD on 14 March. They now own 1,294,774 PRLD shares.

Vaddi Krishna bought 50,000 shares of PRLD on 13 March. They now own 1,264,775 PRLD shares.

Vaddi Krishna bought 47,500 shares of PRLD on 12 March. They now own 1,214,775 PRLD shares.

Combs Andrew bought 175,000 shares of PRLD on 4 February. They now own 175,000 PRLD shares.

Vaddi Krishna bought 496,000 shares of PRLD on 4 February. They now own 496,000 PRLD shares.

Scherle Peggy bought 175,000 shares of PRLD on 4 February. They now own 175,000 PRLD shares.

Lim Bryant David bought 200,000 shares of PRLD on 4 February. They now own 200,000 PRLD shares.

Huang Jane bought 200,000 shares of PRLD on 4 February. They now own 200,000 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 January. They now own 72,716 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 January. They now own 46,875 PRLD shares.

Huang Jane sold 3,859 shares of PRLD on 4 January. They now own 68,857 PRLD shares.

Vaddi Krishna bought 5,000 shares of PRLD on 31 December. They now own 142,553 PRLD shares.

Vaddi Krishna bought 10,000 shares of PRLD on 30 December. They now own 137,553 PRLD shares.

Combs Andrew bought 60,000 shares of PRLD on 23 December. They now own 377,623 PRLD shares.

Combs Andrew bought 3,075 shares of PRLD on 20 December. They now own 317,623 PRLD shares.

Vaddi Krishna bought 6,888 shares of PRLD on 19 December. They now own 127,553 PRLD shares.

Lim Bryant David bought 25,000 shares of PRLD on 19 December. They now own 27,400 PRLD shares.

Vaddi Krishna bought 100,000 shares of PRLD on 18 December. They now own 1,167,275 PRLD shares.

Huang Jane sold 3,347 shares of PRLD on 4 July. They now own 57,315 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 July. They now own 60,662 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 July. They now own 65,625 PRLD shares.

Babler Martin bought 23,500 shares of PRLD on 14 June. They now own 23,500 PRLD shares.

Sandor Victor bought 23,500 shares of PRLD on 14 June. They now own 23,500 PRLD shares.

Bonita David P bought 23,500 shares of PRLD on 14 June. They now own 23,500 PRLD shares.

Dier Mardi bought 23,500 shares of PRLD on 14 June. They now own 23,500 PRLD shares.

Baker Bros. Advisors Lp bought 23,500 shares of PRLD on 14 June. They now own 23,500 PRLD shares.

Friedman Paul A bought 23,500 shares of PRLD on 14 June. They now own 23,500 PRLD shares.

Lim Bryant David bought 25,000 shares of PRLD on 14 May. They now own 25,000 PRLD shares.

Huang Jane sold 3,347 shares of PRLD on 4 April. They now own 51,287 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 April. They now own 75,000 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 April. They now own 54,634 PRLD shares.

Chardonnet Laurent bought 150,000 shares of PRLD on 1 March. They now own 150,000 PRLD shares.

Combs Andrew bought 150,000 shares of PRLD on 1 March. They now own 150,000 PRLD shares.

Huang Jane bought 175,000 shares of PRLD on 1 March. They now own 175,000 PRLD shares.

Vaddi Krishna bought 425,000 shares of PRLD on 1 March. They now own 425,000 PRLD shares.

Scherle Peggy bought 150,000 shares of PRLD on 1 March. They now own 150,000 PRLD shares.

Lim Bryant David bought 150,000 shares of PRLD on 1 March. They now own 150,000 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 January. They now own 49,103 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 January. They now own 84,375 PRLD shares.

Huang Jane sold 3,844 shares of PRLD on 4 January. They now own 45,259 PRLD shares.

Baker Bros. Advisors Lp bought 593,452 shares of PRLD on 13 December. They now own 1,563,672 PRLD shares.

Baker Bros. Advisors Lp bought 7,343,307 shares of PRLD on 13 December. They now own 17,968,343 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 October. They now own 93,750 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 October. They now own 39,728 PRLD shares.

Huang Jane sold 9,375 shares of PRLD on 4 July. They now own 103,125 PRLD shares.

Huang Jane sold 3,242 shares of PRLD on 4 July. They now own 30,353 PRLD shares.

Huang Jane bought 9,375 shares of PRLD on 4 July. They now own 33,595 PRLD shares.

Bonita David P bought 23,500 shares of PRLD on 16 June. They now own 23,500 PRLD shares.

Dier Mardi bought 23,500 shares of PRLD on 16 June. They now own 23,500 PRLD shares.

Babler Martin bought 23,500 shares of PRLD on 16 June. They now own 23,500 PRLD shares.

Baker Bros. Advisors Lp bought 23,500 shares of PRLD on 16 June. They now own 23,500 PRLD shares.

Sandor Victor bought 23,500 shares of PRLD on 16 June. They now own 23,500 PRLD shares.

Friedman Paul A bought 23,500 shares of PRLD on 16 June. They now own 23,500 PRLD shares.

Vaddi Krishna bought 900 shares of PRLD on 25 May. They now own 1,067,275 PRLD shares.

Vaddi Krishna bought 1,000 shares of PRLD on 24 May. They now own 1,066,375 PRLD shares.

Lim Bryant David bought 2,400 shares of PRLD on 24 May. They now own 2,400 PRLD shares.

Chardonnet Laurent bought 5,000 shares of PRLD on 23 May. They now own 42,165 PRLD shares.

Vaddi Krishna bought 11,856 shares of PRLD on 23 May. They now own 1,065,375 PRLD shares.

Baker Bros. Advisors Lp bought 970,220 shares of PRLD on 22 May. They now own 970,220 PRLD shares.

Baker Bros. Advisors Lp bought 121,178 shares of PRLD on 22 May. They now own 630,658 PRLD shares.

Bonita David P bought 869,565 shares of PRLD on 22 May. They now own 10,119,756 PRLD shares.

Baker Bros. Advisors Lp bought 1,327,044 shares of PRLD on 22 May. They now own 6,539,415 PRLD shares.

Baker Bros. Advisors Lp bought 10,625,036 shares of PRLD on 22 May. They now own 10,625,036 PRLD shares.

Orbimed Advisors Llc bought 869,565 shares of PRLD on 22 May. They now own 10,119,756 PRLD shares.

Huang Jane sold 13,280 shares of PRLD on 6 April. They now own 24,220 PRLD shares.

Huang Jane sold 37,500 shares of PRLD on 4 April. They now own 112,500 PRLD shares.

Huang Jane bought 37,500 shares of PRLD on 4 April. They now own 37,500 PRLD shares.

Lim Bryant David bought 250,000 shares of PRLD on 1 March. They now own 250,000 PRLD shares.

Lim Bryant David bought 0 shares of PRLD on 20 February. They now own 0 PRLD shares.

Chardonnet Laurent bought 135,000 shares of PRLD on 7 February. They now own 135,000 PRLD shares.

Combs Andrew bought 135,000 shares of PRLD on 7 February. They now own 135,000 PRLD shares.

Scherle Peggy bought 135,000 shares of PRLD on 7 February. They now own 135,000 PRLD shares.

Vaddi Krishna bought 330,000 shares of PRLD on 7 February. They now own 330,000 PRLD shares.

Huang Jane bought 150,000 shares of PRLD on 7 February. They now own 150,000 PRLD shares.

Chardonnet Laurent bought 75,000 shares of PRLD on 21 December. They now own 75,000 PRLD shares.

Vaddi Krishna bought 19,188 shares of PRLD on 20 December. They now own 120,665 PRLD shares.

Chardonnet Laurent bought 10,000 shares of PRLD on 8 December. They now own 35,873 PRLD shares.

Babler Martin bought 31,293 shares of PRLD on 17 June. They now own 31,293 PRLD shares.

Dier Mardi bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Bonita David P bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Sandor Victor bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Bonita David P bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Baker Bros. Advisors Lp bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Babler Martin bought 31,293 shares of PRLD on 17 June. They now own 31,293 PRLD shares.

Friedman Paul A bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Baker Brothers Life Sciences Lp bought 34,300 shares of PRLD on 17 June. They now own 34,300 PRLD shares.

Chardonnet Laurent bought 10,000 shares of PRLD on 1 June. They now own 24,500 PRLD shares.

Huang Jane bought 150,000 shares of PRLD on 2 May. They now own 150,000 PRLD shares.

Huang Jane bought 0 shares of PRLD on 4 April. They now own 0 PRLD shares.

Combs Andrew sold 36,062 shares of PRLD on 1 April. They now own 50,397 PRLD shares.

Combs Andrew sold 36,062 shares of PRLD on 31 March. They now own 50,397 PRLD shares.

Combs Andrew bought 36,062 shares of PRLD on 31 March. They now own 304,442 PRLD shares.

Chardonnet Laurent bought 6,500 shares of PRLD on 21 March. They now own 14,500 PRLD shares.

Chardonnet Laurent bought 90,000 shares of PRLD on 15 February. They now own 90,000 PRLD shares.

Combs Andrew bought 100,000 shares of PRLD on 15 February. They now own 100,000 PRLD shares.

Scherle Peggy bought 100,000 shares of PRLD on 15 February. They now own 100,000 PRLD shares.

Morosini Deborah bought 90,000 shares of PRLD on 15 February. They now own 90,000 PRLD shares.

Vaddi Krishna bought 327,900 shares of PRLD on 15 February. They now own 327,900 PRLD shares.

Sandor Victor bought 11,206 shares of PRLD on 3 January. They now own 11,206 PRLD shares.

Morosini Deborah bought 3,016 shares of PRLD on 15 December. They now own 3,460 PRLD shares.

Morosini Deborah bought 25,735 shares of PRLD on 15 December. They now own 29,195 PRLD shares.

Morosini Deborah sold 24,853 shares of PRLD on 15 December. They now own 74,575 PRLD shares.

Morosini Deborah sold 882 shares of PRLD on 15 December. They now own 195,163 PRLD shares.

Morosini Deborah sold 3,016 shares of PRLD on 15 December. They now own 1,307 PRLD shares.

Morosini Deborah sold 28,751 shares of PRLD on 15 December. They now own 444 PRLD shares.

Combs Andrew bought 4,000 shares of PRLD on 14 December. They now own 268,380 PRLD shares.

Chardonnet Laurent bought 5,000 shares of PRLD on 13 December. They now own 8,000 PRLD shares.

Combs Andrew bought 4,000 shares of PRLD on 13 December. They now own 264,380 PRLD shares.

Vaddi Krishna bought 8,000 shares of PRLD on 13 December. They now own 1,053,519 PRLD shares.

Chardonnet Laurent sold 0 shares of PRLD on 29 November. They now own 3,000 PRLD shares.

Chardonnet Laurent bought 180,000 shares of PRLD on 29 November. They now own 180,000 PRLD shares.

Morosini Deborah sold 400 shares of PRLD on 16 November. They now own 444 PRLD shares.

Morosini Deborah bought 28,751 shares of PRLD on 16 November. They now own 29,195 PRLD shares.

Morosini Deborah sold 28,351 shares of PRLD on 16 November. They now own 844 PRLD shares.

Morosini Deborah sold 28,751 shares of PRLD on 16 November. They now own 196,045 PRLD shares.

Sandor Victor bought 8,022 shares of PRLD on 13 October. They now own 8,022 PRLD shares.

Mauro David J sold 15,000 shares of PRLD on 5 October. They now own 137,610 PRLD shares.

Mauro David J sold 5,908 shares of PRLD on 5 October. They now own 9,092 PRLD shares.

Mauro David J sold 7,803 shares of PRLD on 5 October. They now own 1,289 PRLD shares.

Mauro David J bought 15,000 shares of PRLD on 5 October. They now own 15,000 PRLD shares.

Mauro David J sold 1,289 shares of PRLD on 5 October. They now own 0 PRLD shares.

Mauro David J sold 7,487 shares of PRLD on 7 September. They now own 7,513 PRLD shares.

Mauro David J sold 4,640 shares of PRLD on 7 September. They now own 0 PRLD shares.

Mauro David J sold 2,873 shares of PRLD on 7 September. They now own 4,640 PRLD shares.

Mauro David J sold 15,000 shares of PRLD on 7 September. They now own 167,610 PRLD shares.

Mauro David J bought 15,000 shares of PRLD on 7 September. They now own 15,000 PRLD shares.

Pierce Christopher sold 6,727 shares of PRLD on 2 September. They now own 10,680 PRLD shares.

Pierce Christopher bought 17,000 shares of PRLD on 2 September. They now own 20,750 PRLD shares.

Pierce Christopher sold 3,343 shares of PRLD on 2 September. They now own 17,407 PRLD shares.

Pierce Christopher sold 17,000 shares of PRLD on 2 September. They now own 207,796 PRLD shares.

Pierce Christopher sold 6,930 shares of PRLD on 2 September. They now own 3,750 PRLD shares.

Scherle Peggy sold 6,014 shares of PRLD on 27 August. They now own 27,018 PRLD shares.

Scherle Peggy sold 2,707 shares of PRLD on 27 August. They now own 173,527 PRLD shares.

Scherle Peggy sold 2,700 shares of PRLD on 27 August. They now own 176,234 PRLD shares.

Scherle Peggy sold 607 shares of PRLD on 27 August. They now own 172,920 PRLD shares.

Scherle Peggy bought 6,014 shares of PRLD on 27 August. They now own 178,934 PRLD shares.

Scherle Peggy sold 1,700 shares of PRLD on 26 August. They now own 33,032 PRLD shares.

Scherle Peggy bought 1,700 shares of PRLD on 26 August. They now own 174,620 PRLD shares.

Scherle Peggy sold 1,700 shares of PRLD on 26 August. They now own 172,920 PRLD shares.

Piper Brian sold 3,889 shares of PRLD on 25 August. They now own 2,344 PRLD shares.

Piper Brian sold 2,344 shares of PRLD on 25 August. They now own 0 PRLD shares.

Piper Brian sold 2,100 shares of PRLD on 25 August. They now own 6,233 PRLD shares.

Piper Brian sold 8,333 shares of PRLD on 25 August. They now own 264,329 PRLD shares.

Piper Brian bought 8,333 shares of PRLD on 25 August. They now own 8,333 PRLD shares.

Scherle Peggy sold 558 shares of PRLD on 13 August. They now own 42,672 PRLD shares.

Scherle Peggy sold 1,728 shares of PRLD on 13 August. They now own 34,732 PRLD shares.

Scherle Peggy sold 2,286 shares of PRLD on 13 August. They now own 172,920 PRLD shares.

Scherle Peggy bought 1,728 shares of PRLD on 13 August. They now own 175,206 PRLD shares.

Scherle Peggy bought 558 shares of PRLD on 13 August. They now own 173,478 PRLD shares.

Mauro David J sold 2,063 shares of PRLD on 5 August. They now own 6,821 PRLD shares.

Mauro David J sold 6,116 shares of PRLD on 5 August. They now own 8,884 PRLD shares.

Mauro David J sold 6,721 shares of PRLD on 5 August. They now own 100 PRLD shares.

Mauro David J bought 15,000 shares of PRLD on 5 August. They now own 15,000 PRLD shares.

Mauro David J sold 15,000 shares of PRLD on 5 August. They now own 167,610 PRLD shares.